Clinical Features
The hematologic diseases treated in the hospital includes: leukemia, Non-Hodgkin’s lymphoma and Hodgkin’s lymphoma, multiple myeloma, myelodysplastic syndrome, severe aplastic anemia, myelofibrosis, etc.
In 1992, the first autologous stem cell transplant was performed, and in 1997, the first allogenic stem cell transplant was performed in the department. In 1999, a patients with severe aplastic anemia and pyocyanic septicemia was successfully treated by allogeneic peripheral stem cell transplantation, which provided a totally new option for the treatment of severe aplastic anemia in China. In 2000, a 10-year-old girl with severe aplastic anemia was successfully treated with allogenic umbilical cord blood stem cells transplant, which was the first case report in China. In 2001, Dr.  Chun Wang published a theme report titled “Chun Wang On oncology in China” on Lancet Oncology.

In 2002, the first tandem transplant for multiple myeloma in China was performed in the department, i.e. autologous transplant followed by non-myeloablative allogenic transplant, the patient has been in disease free until now. In 2010, the collaboration with Fudan University affiliated Shanghai Tumor Hospital for the treatment of refractory lymphoma was established, many patients with refractory and relapsed lymphoma in Shanghai Tumor Hospital were referred to the department of hematology for autologous or allogeneic transplant. In recent years, several national wide multicenter randomized clinical trials on acute myelogenous leukemia, severe aplastic anemia, and aggressive T cell lymphoma were carried out, etc. In 2013, a national wide multicenter randomized prospective clinical trial on prevention and treatment of invasive fungal infection after allogeneic stem cell transplantation were fulfilled, the original article was published on Journal of Clinical Oncology in 2015.

Successful treatment starts with an accurate diagnosis. Laboratory technicians are specially trained to recognize different hematological disorders by bone marrow smear, flow cytometry, cytogenetics, fusion gene by PCR and FISH, and pathology of bone marrow and lymph nodes. Further, next generation sequencing help doctors give patients precise diagnosis and treatment. In addition, for chimerism analysis, short tandem repeats (STR) by PCR and XY chromosome by FISH based on flow cytometry cell sorting technique greatly improved recipients’ survival after allogeneic hematopoietic stem cell transplantation.