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The Reproductive Center of Shanghai General Hospital Adopted the New Technology of "Pre-implantation Genetic Testing" to Complete Our First "Third Generation IVF"

Link of original article:

https://mp.weixin.qq.com/s/iTGLaPbxnHep8iHrinsrqg


Recently, the Reproductive Center of Shanghai General Hospital adopted the "Preimplantation Genetic Testing (PGT)" technology for the first time in our hospital to perform embryo genetic testing and obtain normal embryos, helping a couple to have successful pregnancy and deliver a health baby. This marks a new level of assisted reproduction technology at Shanghai General Hospital.


Ms. Wang (pseudonym) has been married for 4 years and has not been pregnant after marriage. Her husband was found to be obstructive azoospermia. The couple came to the team of Li Zheng, director of the andrology department of the urology center and the deputy director of the Reproductive Center at Shanghai General Hospital. After careful examination and evaluation of Ms. Wang's husband, Li's team performed testicular microsurgery. The results showed that although a very small number of sperm could be seen under the microscope, there were very few motile sperm with normal morphology after in vitro culture observation, and there were serious head deformities in sperm. As severe head deformity of sperm may lead to high abortion rate and high birth defect rate, Ms. Wang and her husband did not immediately undergo assisted reproductive surgery. The andrology team thus carried out rare sperm freezing for Ms. Wang's husband and preserved the precious sperm.


In July 2021, our hospital officially launched the pre-implantation genetic testing (PGT) technology, and Ms. Wang and her husband came to the hospital again for help. After careful consultation, the team of the Reproductive Center determined that they were qualified for the "Third Generation IVF" , and decided to use the technology to help them. With the joint efforts of Wu Yu, deputy director of the Reproductive Center, the woman underwent ovulation induction and oocyte retrieval. At the same time, the man's rare sperm was resuscitated, and intracytoplasmic sperm injection (ICSI) was performed. After culture, several blastocysts were successfully obtained and PGT was tested. The results showed that no chromosomal abnormalities were found. In September, 2021, a normal embryo was transplanted into Ms. Wang's uterus. She was pregnant successfully. Subsequent amniocentesis and other detection also confirmed that the fetal chromosome was normal. Recently, Ms. Wang successfully passed cesarean section and delivered. At present, all indicators of the mother and baby are normal.


According to reports, preimplantation genetic testing (PGT), commonly known as the "Third Generation IVF" technology, refers to the extraction of some cells from embryos formed in vitro before implantation into the mother's uterus for chromosome number, structure and gene testing, and then embryos with normal chromosome karyotype or without genetic diseases are selected to be transplanted into the uterus, so as to obtain healthy offspring. PGT technology helps to screen out problematic embryos, so as to improve the pregnancy rate, reduce the abortion rate, and advance the prevention of genetic diseases to the pre pregnancy stage. PGT can also be used to improve pregnancy rate, live birth rate and pregnancy outcome in patients with recurrent abortion and implantation failure.


With the support of the hospital, the Reproductive Center at Shanghai General Hospital was qualified for the trial run of pre-implantation genetic testing technology in July 2021 after preliminary technical exploration and thorough preparation. So far, in addition to Ms. Wang, who successfully gave birth to the first "Third Generation IVF" baby, more than 40 patients have been treated with PGT, and the pregnancy rate among patients who underwent blastocyst transfer reached 60%.


Correspondent: Wu Yu, Zhang Jiawen, the Reproductive Center, Hu Yang, Department of Publicity

Editor: Cai Shishi, Department of Publicity


 


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